Genetika, biološka dob i mišićna vlakna u razvoju sportskog talentaGenetics, biological age and muscle fibres in talent development
TWINSWINS je međunarodni interdisciplinarni projekt koji istražuje genetske i biološke temelje sportskog talenta i atletske izvedbe.TWINSWINS is an international interdisciplinary project investigating the genetic and biological foundations of sporting talent and athletic performance.
Sažetak projektaProject summary
Projekt TWINSWINS (The Interplay of Genetics, Biological Age, and Muscle Fiber Characteristics in Talent Development and Athletic Performance) sustavno istražuje međuigru genetskih, bioloških i mišićnih čimbenika koji određuju razvoj sportskog talenta i atletsku izvedbu. Projekt sufinanciraju Hrvatska zaklada za znanost (HRZZ) i Agencija za raziskovalno in inovacijsko dejavnost Republike Slovenije (ARIS), a provodbe ga Kineziološki fakultet Sveučilišta u Splitu (KIFST) u partnerstvu s Fakultetom za šport Sveučilišta u Ljubljani.
The TWINSWINS project (The Interplay of Genetics, Biological Age, and Muscle Fiber Characteristics in Talent Development and Athletic Performance) systematically investigates the interplay of genetic, biological and muscular factors that shape athletic talent development and performance. The project is co-funded by the Croatian Science Foundation (HRZZ) and the Slovenian Research and Innovation Agency (ARIS), and is conducted by the Faculty of Kinesiology, University of Split (KIFST) in partnership with the Faculty of Sport, University of Ljubljana.
Ključni ciljevi uključuju:Key objectives include:
- Uspostavu Cro Sport Talent Laba — multidisciplinarnog laboratorija za genotipizaciju, procjenu biološke dobi i analizu mišićnih vlakana sportaša.Establishing the Cro Sport Talent Lab — a multidisciplinary laboratory for genotyping, biological age assessment and muscle fibre analysis of athletes.
- Analizu genetskih polimorfizama vezanih uz tip mišićnih vlakana, biološku dob i sportsku izvedbu u različitim skupinama sportaša.Analysing genetic polymorphisms linked to muscle fibre type, biological age and athletic performance across different athlete groups.
- Istraživanje odnosa biološke dobi, epigenetskih biomarkera i sportskog uspjeha uz usporedbu jednojajčanih i dvojajčanih blizanaca.Investigating the relationship between biological age, epigenetic biomarkers and athletic success, with comparison of monozygotic and dizygotic twin pairs.
- Validaciju neinvazivnih metoda procjene tipa mišićnih vlakana (TMG, beta-alanin iz sline, bliska infracrvena spektroskopija).Validating non-invasive methods for assessing muscle fibre type (TMG, salivary beta-alanine, near-infrared spectroscopy).
- Razvoj prediktivnog modela za identifikaciju sportskog talenta koji integrira genetske, biološke i funkcionalne pokazatelje.Developing a predictive model for talent identification that integrates genetic, biological and functional indicators.
Projekt je logičan nastavak ranijeg HRZZ projekta IP-2020-02-3366 („Biološka, kronološka i relativna dob u uspostavi hrvatskog sustava sportskih talenata") i nadograđuje uspostavljenu infrastrukturu i stečena znanja u polje genomike i epigenetike sportskih talenata.
The project is a logical continuation of the earlier HRZZ project IP-2020-02-3366 ("Biological, chronological and relative age in establishing the Croatian sports talent system") and builds upon the established infrastructure and acquired knowledge into the field of genomics and epigenetics of sporting talent.
Zašto je ovaj projekt neophodan?Why is this project essential?
Suvremeni sustavi identifikacije talenata u sportu oslanjaju se pretežno na morfološke i motoričke testove koji odražavaju trenutnu fizičku razvijenost, a ne dugoročni potencijal. Efekt relativne dobi, biološka razvojna nejednakost i zanemarena genetska komponenta dovode do toga da mnogi iznimno talentirani mladi sportaši bivaju propušteni ili napuste sport prerano.
Modern talent identification systems in sport rely predominantly on morphological and motor tests that reflect current physical development rather than long-term potential. The relative age effect, biological developmental inequality and a neglected genetic component mean that many exceptionally talented young athletes are overlooked or leave sport prematurely.
TWINSWINS nudi holistički, multi-omički pristup koji kombinira genomiku, epigenetiku, procjenu biološke dobi i analizu mišićnih vlakana u jedinstven model predviđanja sportskog potencijala.
TWINSWINS offers a holistic, multi-omics approach that combines genomics, epigenetics, biological age assessment and muscle fibre analysis into a unique model for predicting sporting potential.
Prethodni HRZZ projektPrevious HRZZ project
TWINSWINS je nastavak projekta IP-2020-02-3366 u sklopu kojeg je razvijen sustav procjene sportskih talenata u Hrvatskoj i uspostavljen Cro Sport Talent & Longevity Health Lab. Stečena metodološka osnova, baza podataka i partnerska mreža čine temelj ovog novog projekta.
TWINSWINS continues project IP-2020-02-3366, during which a sports talent assessment system was developed in Croatia and the Cro Sport Talent & Longevity Health Lab established. The acquired methodological foundation, database and partner network underpin this new project.
Pet ciljeva projektaFive project objectives
Genetski profiliGenetic profiles
Analizirati genetske polimorfizme (ACTN3, ACE, PPARGC1A i dr.) u skupinama sportaša različitih disciplina i razina, uključujući parove blizanaca.
Analyse genetic polymorphisms (ACTN3, ACE, PPARGC1A etc.) in athlete groups across disciplines and levels, including twin pairs.
Biološka dob i epigenetikaBiological age & epigenetics
Istražiti odnos između epigenetske dobi (GlycanAge, DNK metilacija, telomeri) i sportskih pokazatelja te usporediti jednojajčane i dvojajčane blizance.
Investigate the relationship between epigenetic age (GlycanAge, DNA methylation, telomeres) and athletic indicators, comparing monozygotic and dizygotic twins.
Neinvazivna procjena vlakanaNon-invasive fibre assessment
Validirati i usporediti neinvazivne metode procjene tipa mišićnih vlakana: TMG, beta-alanin iz sline i bliska infracrvena spektroskopija.
Validate and compare non-invasive methods for assessing muscle fibre type: TMG, salivary beta-alanine and near-infrared spectroscopy.
Prediktivni model talentaTalent predictive model
Razviti integrirani prediktivni model koji kombinira genetske, epigenetske, biološke i funkcionalne pokazatelje za poboljšanje identifikacije i dugoročnog razvoja sportskih talenata.
Develop an integrated predictive model combining genetic, epigenetic, biological and functional indicators to improve talent identification and long-term talent development.
Tri godine, tri fazeThree years, three phases
Uspostava i pripremaSetup & preparation
Nabava i instalacija opreme (TMG, NIR spektrometar, kit za genotipizaciju, GlycanAge, nosivi senzori), uspostava laboratorija, regrutacija ispitanika i parova blizanaca, izrada protokola, etičko odobrenje, pilot-studija.
Procurement and installation of equipment (TMG, NIR spectrometer, genotyping kit, GlycanAge, wearables), lab setup, recruitment of participants and twin pairs, protocol development, ethical approval, pilot study.
Mjerenja i prikupljanje podatakaMeasurements & data collection
Genotipizacija, procjena biološke dobi (epigenetski satovi, GlycanAge), neinvazivna procjena mišićnih vlakana (TMG, beta-alanin iz sline, NIR), antropometrija, motorički testovi, slina i krvni uzorci, analiza parova blizanaca. Lokacije: Split i Ljubljana.
Genotyping, biological age assessment (epigenetic clocks, GlycanAge), non-invasive muscle fibre assessment (TMG, salivary beta-alanine, NIR), anthropometry, motor tests, saliva and blood samples, twin pair analysis. Locations: Split and Ljubljana.
Analiza, modeli i diseminacijaAnalysis, models & dissemination
Integrirana statistička analiza, razvoj prediktivnog modela (strojno učenje), usporedba metoda, objava rezultata u međunarodnim časopisima Q1/Q2, konferencijski nastupi, diseminacija prema stručnoj i laičkoj javnosti.
Integrated statistical analysis, predictive model development (machine learning), method comparison, publication of results in international Q1/Q2 journals, conference presentations, dissemination to both specialist and general audiences.